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CURRENT ISSUEGAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2015 November;174(11):513-8

language: English

Inflammatory and cardiac responses after long distance cycling at controlled moderate-intensity in a female athlete: a case report

Azevedo L. F. 1, Dos Santos M. R. 1, Jordao C. P. 2

1 Medical School of University of Sao Paulo, Sao Paulo, Brazil;
2 Cardiovascular Rehabilitation and Exercise Physiology Unit, Heart Institute of Clinical Hospital of Medical School of University of Sao Paulo, Sao Paulo, Brazil


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This case evaluated the inflammatory, cardiac and hormonal responses after a long distance cycling performed at controlled moderate-intensity in a female amateur athlete. Cardiopulmonary test, echocardiography and blood exams were taken before and after the race. Heart rate (HR) was monitored throughout the race. The race was performed in 11 hours and 29 minutes and HR was within ventilatory thresholds range (moderate-intensity) during 96% of the total time. After the race CPK increased slightly beyond the reference range and creatinine increased, but within the normal range. Although hsCRP and BNP (cardiac markers) had increased about 3 times after the race, Troponin I had not changed. Leukocytosis was observed. Three pro-inflammatory markers increased (IL-1α, TNFα and TNFβ), one (IL-1β) decreased while one anti-inflammatory marker increased (IL-10) after the race. Cortisol, ACTH, GH and IGF-1 decreased after the race. None cardiac dysfunction or abnormal structural adaptation was observed after the race. A single bout of long distance cycling performed at controlled moderate-intensity provoked changes in blood biomarkers (inflammation) and hormones without cardiac dysfunction in a female athlete. Light inflammatory alterations and decrease in hormones could be expected after long duration exercise as a physiological response to this stimulus.

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