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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2015 May;174(5):225-31
Aerobic exercise without multivitamin supplementation increased serum homocysteine levels
Dinç N. 1, Bereket-Yücel S. 1, Taneli F. 2, Ulman C. 2, Tikiz H. 3
1 Department of Kinesiology and Training, School of Physical Education and Sports, Celal Bayar University, Izmir, Turkey;
2 Department of Biochemistry, School of Medicine, Celal Bayar University, Izmir, Turkey;
3 Department of Cardiology, School of Medicine, Celal Bayar University, Izmir, Turkey
AIM: Aim of the study was to investigate the effects of aerobic exercise on cardiovascular risk factors such as Serum total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL), triglyceride (TG), lipoprotein (a)Lp(a), apolipoprotein A (Apo A), apolipoprotein B (Apo B), and homocysteine (Hcy) levels and to evaluate the impact of additional multivitamin supplementation on these parameters.
METHODS: Sixty volunteers (23.01±3.71 yrs, 173.20±9.88 cm, 69.32±12.52 kg, 22.92±2.64 kg/m2) were enrolled in the study and randomized into the following 3 groups; multivitamin (MVG), placebo (PG) and control (CG). The volunteers in the MVG and PG attended 8 weeks of aerobic training program which was prescribed individually according to 60% of their maximum VO2. MVG were given a multivitamin supplement while PG were taken a placebo once daily for 8 weeks.
RESULTS: The analysis of the data indicated that the Hcy level of PG was significantly higher after 8 weeks of aerobic training, F (1, 16) = 17.70, p=0.00. The increase in the MVG was not statistically significant after the multivitamin supplementation and aerobic training, p≥0.05. Unexpectedly, the simple effect analysis showed that there was a statistically significant decrease in HDL levels of both MVG and PG after eight weeks of aerobic training, F(1, 17) = 7.67, p=0.01, F(1, 16) = 16.00, p=0.02, respectively.
CONCLUSION: Without multivitamin supplementation, aerobic exercise could lead to a significant increase in Hcy levels which has been considered an important cardiovascular risk factor. It is also possible that the baseline HDL levels of the participants could be another physiological variable that cause changes in the Hcy metabolism.