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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2015 January-February;174(1-2):65-70

language: English

A retrospective analysis of the clinical diagnosis and treatment of Chinese patients with Gitelman’s Syndrome

Ding J. 1, Li C. 2

1 Department of Endocrinology, Zhenghai Longsai Hospital, Ningbo, China;
2 Department of Endocrinology, First Affiliated Hospital Zhejiang, University School of Medicine Hangzhou, China


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AIM: Aim of the study was to facilitate the diagnosis and treatment of Gitelman’s Syndrome (GS) by retrospectively analyzing the clinical features and treatment within a Chinese patient population.
METHODS: This study retrospectively analyzed the clinical presentation, biochemical values and therapy of 15 Chinese patients with GS (7 male and 8 female, age 15-56 yr). The clinical symptoms and biochemical measurements of the patients were recorded. The action of the renin-angiotensin-aldosterone system was evaluated in the supine-orthostatic test by measuring the plasma level of renin activity (PRA), angiotensin II (AT II) and aldosterone (Ald).
RESULTS: Patients presented mainly with muscle weakness, cramps, nocturia and numbness. Biochemical values showed hypokalemia, hypomagnesemia, low urinary calcium excretion and metabolic alkalosis. The PRA, AT II and Ald levels varied above normal values when in supine or erect positions. Following treatment with potassium and magnesium supplements combined with spironolactone (60 mg/day) or indomethacin (75 mg/day), the clinical manifestations improved; however, the plasma potassium and magnesium levels did not completely normalize following two weeks of treatment.
CONCLUSION: GS presented with clinical symptoms consistent with hypokalemia and hypomagnesemia in this Chinese patient population. Supplementation of potassium and magnesium was utilized as the main treatment.

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