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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Duk Oh S.
College of Physical Education Hanyang University, Seoul, Korea
Aim: The increase of total homocysteine level (tHcy) is a novel risk factor of cardiovascular diseases, and the C677T polymorphism in the vmethylenetetrahydrofolate reductase (MTHFR) gene is associated with the inter-individual differences of tHcy level. The object of this study was to investigate the distribution of the C677T polymorphism within the methylenetetrahydrofolate reductase (MTHFR) gene in Korean male athletes and controls, and its association with several cardiovascular risk factors, respectively.
Methods: Biochemical parameters such as serum total cholesterol (TC), triglyceride (TG), HDL-cholesterol, lipoprotein(a) (Lp(a)), folate, total homocysteine (tHcy) and plasma glucose levels were assayed by automatic analyzer, and data on cardiac structure and function measured by M-mode echocardiography, respectively. In the case of the C677T polymorphism within MTHFR gene, SNaPshot method was used.
Results: Although significant difference in the distribution of the C677T polymorphism were not observed between our controls and athletes as well as each subgroup of athletes, this polymorphism were significantly associated with serum tHcy level in the both groups, respectively (P<.05). In the case of athletes, the significant association were also detected between the C677T polymorphism and several echocardiographic data, respectively (P<.05).
Conclusion: In summary, our data reflect the fact that the C677T polymorphism within MTHFR gene may be a useful genetic marker for homocysteine metabolism and cardiovascular function in especially athletic group.