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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Grigoryan O., Absatarova J., Andreeva E., Melnichenko G., Dedov I.
Federal State Facility, Endocrinological Scientific Centre under the RF Ministry of Public Health, Moscow, Russia
Aim: Women with type 1 diabetes mellitus (T1DM) and polycystic ovary syndrome (PCOS) have normal level of sex hormone binding globulin, suggesting that the pathophysiology of hyperandrogenism in PCOS patients with T1DM appears to be different from that in PCOS without T1DM. The aim of this study is a definition of hormonal features in women with PCOS and T1DM.
Methods: The study included 50 women (mean age 27.4±6.9 years) with PCOS, including 25 with T1DM and satisfactory glycemic control, the level of glycosylated hemoglobin was 5.8±0.8%, and 25 without carbohydrate metabolism disturbance. The control group included 25 healthy women with normal menstrual cycle (22-34 days). All patients underwent an examination, including assessment of anthropometric data (BMI was calculated as weight/height2 (kg/m2), Ferriman-Gallwey hirsutism score, Ludwig alopecia score, pelvic ultrasound and research a concentration of hormones in the blood serum.
Results: Hirsutism is less severe and oligomenorrhea is less common in women with T1DM and PCOS compared with nondiabetic PCOS women.
Conclusion: Physicians, treating women with T1DM should be aware of the risk of hyperandrogenism and include evaluation of hirsutism, menstrual disorders, and biochemical hyperandrogenism into routine examinations.