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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2014 January-February;173(1-2):71-4
Twin pregnancy with complete hydatidiform mole and coexisting normal fetus complicated by molar previa and incorrect low levels of β-hCG
Kurt S., Uyar I., Demirtas O., Tan N., Tasyurt A.
Department of Obstetrics and Gynecology Tepecik Education and Research Hospital Izmir, Turkey
Twin pregnancy with complete hydatidiform mole and co-existing normal fetus is a rare clinical condition. Previa presentation of molar component is unusual. The course of these pregnancies depend on related complications of molar component such as early onset preeclampsia, hyperthyroidism, vaginal bleeding, preterm birth and intrauterine fetal demise. Twin pregnancy with complete mole and 18 gestational week normal fetus was admitted to our clinic. Laboratory tests resulted in anemia and very low level of β-hCG. Urine pregnancy test was incorrect negative. After dilution, β-hCG test was dramatically high. This condition is known as the “hook effect” in the literature. Posterior location of normal placenta and previa location of molar component were explored under ultrasonography. Genetic amniocentesis was performed for the fetus which was revealed 46,XY karyotype and CVS from the molar placenta revealed 46,XX. The pregnancy was terminated due to preeclampsia and vaginal bleeding. The histopathological findings have been reported immature fetal structure and hydatidiform mole. Serum β-hCG level decreased and the patient was followed up for the persistent trophoblastic disease.