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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2013 December;172(12):911-5
Medical treatment by Gorei-san (TJ-17) only or with other hemostatic agents for chronic subdural hematoma without operations
Asano S., Watanabe T., Shinohara T., Fujii N., Ogawa A., Takanashi S., Tanaka J., Naito Y., Ueno T., Furuya K., Nakagomi T.
Department of Neurosurgery,Teikyo University School of Medicine, Tokyo, Japan
Aim: Recently in Japan we have been using Gorei-san, as one of the recipes of oriental medicine, for the treatment of chronic subdural hematoma (CSDH). We would like to show some effectiveness of Gorei-san and other drug interaction for the medical treatment of CSDH.
Methods: We retrospectively reviewed the medical records of the medical treatment with Gorei-san, who were come in our center between 2010 and 2011.
Results: There were 29 patients (46-94 years old and 62% male) using Gorei-san for the medical treatment of CSDH. Of those, eight patients treated by Gorei-san only, while others treated by Gorei-san and other drugs. In 24 patients CSDH were cured (21 patients) or decreased (three censored cases), on the contrary in four patients they had to take a burr hole opening operation and in one patient the thickness of CSDH increased and censored. In the latter five patients’ group, Gorei-san and ibudilast simultaneously administered, and logistic regression analysis showed the negative interaction between them.
Conclusion: We suggested that medical treatment by Gorei-san with CSDH had some effectiveness but we should pay attention to the drug interaction with Gorei-san and ibudilast.