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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Kim J. Y. 1, Kang K. S. 2, Kang B. Y. 3, Kim H. 4, Lee J. K. 5
1 Division of Rheumatology Department of Internal Medicine School of Medicine, Catholic University of Korea Seoul, Korea;
2 Hanvit Otorhinolaryngology Clinic, Korea;
3 College of Physical Education Hanyang University, Seoul, Korea;
4 Department of Health Promotion and Exercise Daegu University, Kyungsan-City, Korea;
5 Department of Leisure and Sports Sahmyook University, Seoul, Korea
Aim: Chronic sinusitis is a common nasal disease that occurs due to inflammation of the paranasal mucosa, and its etiology is as yet unclear, although various pathogenetic mechanisms have been suggested. Several lines of evidences strongly suggest that genetic factors play an important role in the development and/or the severity of this disease. It has been also established that several cytokines are implicated in the inflammatory process, and therefore, the genes encoding for these cytokines are good candidates to clarify the genetic basis of chronic sinusitis. Thus, we investigated the relationship between the genetic polymorphisms in the several cytokine genes, including the interleukin-1 (IL-1) gene family and tumor necrosis factor (TNF) genes, and chronic sinusitis.
Methods: We collected 51 patients with chronic sinusitis and 80 healthy controls, and we analyzed 6 kinds of genetic polymorphisms in a total of 5 cytokine genes, including the IL-1A, IL-1B, IL-1RN, TNF-α and TNF-β genes. Genotyping was performed by the polymerase-chain reaction – restriction fragment length polymorphism (PCR-RFLP) method, the PCR-direct detection method or SNaPshot method.
Results: According to the case-control comparison, there were no significant differences in the genotypes and allele frequencies of all the genetic polymorphisms that were studied. However, we found that the +3954 polymorphism in the IL-1B gene was significantly associated with the polyp score index of the chronic sinusitis patients (P<0.05).
Conclusion: Our data suggests that +3954 polymorphisms in the IL-1B gene may significantly contribute to the severity of chronic sinusitis in Koreans. Further studies with a larger sample size and other candidate genes are needed.