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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2013 July-August;172(7-8):653-7
Idiopathic granulomatous mastitis associated with risperidone: case report
Cremona F., Tosto C., Agnello G.
Department of General Surgery and Metabolic Diseases, Paolo Giaccone General Hospital Palermo, Italy
Aim: Granulomatous mastitis is a rare benign inflammatory disease of the breast, characterized by non-caseating granulomas without any evidence of infection, pathologically mimicking carcinoma. The differential diagnosis with malign breast disease is often not easy, so it is often initially misdiagnosed and proper treatment is delayed. Surgical biopsy is needed for correct diagnosis and there is still no generally accepted optimal treatment. In our experience a conservative approach seems to be adequate in most cases and in our opinion, surgical treatment is the best therapy. Another option is a long/middle-term steroid treatment. It is mandatory to exclude infectious causes of granulomatous mastitis before corticoid therapy is started.
Methods: In our patient the surgical treatment was planned; excision of the entire lesion, and subsequently neoadjuvant corticosteroid therapy was performed.
Results: The patient has benefit from the operation immediately, with resolution of the disease. The follow-up (on-going), up to now, showed no recurrence of the pathological and no complications, making sure the authors of the efficacy of the surgical treatment.
Conclusion: The purpose of this study is describe the clinical, imaging, and pathologic features of granulomatous lobular mastitis of our patient and discuss diagnostic and therapeutic protocols that we used to diagnose and treat this rare disease. The authors noted that believe in the surgical treatment as the only procedure, performed alone or combined with corticosteroid therapy, to the cure of the patients.