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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2013 June;172(6):541-7

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: Italian

Patient with vulvar, oral and esophageal lichen planus, alopecia, autoimmune thyroiditis and systemic hypertension: suspected for multiple autoimmune syndrome

Catalano C. 1, De Magnis A. 2, Sisti G. 2, Fambrini M. 3

1 Dipartimento di Scienze per la Salute della Donna e del Bambino, AOU Careggi, Firenze, Italia; 2 Servizio di Patologia Vulvare, Dipartimento di Scienze per la Salute della Donna e del Bambino, AOU Careggi, Firenze, Italia; 3 Dipartimento di Scienza per la Salute della Donna e del Bambino, Università di Firenze, Firenze, Italia


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We illustrate case of Lichen Planus esophageal appeared in patient with vulvar Lichen Planus, Oral and pilaris and suspicion for the occurrence of Multiple Autoimmune Syndrome. The Lichen Planus would present, in fact, strong association with autoimmune diseases (alopecia areata , vitiligo, pemphigus, dermatitis herpetiformis, primary biliary cirrhosis, autoimmune hepatitis, autoimmune thyroiditis , pernicious anemia, diabetes mellitus, Lupus Erythematosus Sistemicus and Scleroderma) and, considering its many different clinical expression, it would require a multi-disciplinary approach. In the case we have shown the association of the pictures of vulvar lichen planus and oral with those of alopecia, autoimmune thyroiditis and the appearance of esophageal lichen planus, this has led us to suspecta diagnosis of Multiple Autoimmune Syndrome . The diagnosis of Lichen Planus requires, therefore, to gynecologist, broad multidisciplinary knowledge in interpreting and correlating the anamnesis, the clinical and histopathological, and any extragenital manifestations of autoimmune diseases. Although in our case the clinical, biochemical and instrumental investigations have not led to positive results for the diagnosis of connective tissue, not being present all the necessary criteria, the association between these diseases should always be considered, in the presence of clinical as well varied, also for the possibility that it develops in time a multi autoimmune syndrome.

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