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A Journal on Internal Medicine and Pharmacology

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2013 May;172(5):405-9

language: Italian

Diagnosis and outcome of partial hydatiform mole coexisting with a live fetus: case report

Cunzolo T. 1, Rabino V. 1, Bocci F. 1, Ragno P. 1, Lettieri C. 1, Feyles E. 2, Barbero M. 1

1 SOC Ostetricia e Ginecologia Ospedale Cardinal Massaia ASL AT, Asti, Italia;
2 SOC di Anatomia, Istologia Patologica e Citodiagnostica ASL AT, Asti, Italia


Partial mole is a form of gestational trophoblastic disease that may be associated with serious medical complications and occasionally progress to the second trimester of pregnancy.
Current practices in screening and monitoring during early pregnancy allow for better identification of hydatidiform mole. Ultrasound is the initial imaging investigation of choice when gestational trophoblastic disease is suspected and also serial monitoring of serum human chorionic gonadotropin levels is warranted. We present a case report of a 32-year-old woman, with antecedents of 2 spontaneous abortion. She present a partial mole diagnosed on ultrasound for persistent vaginal bleeding at 19 weeks of gestation with a normal fetus in uterus. The couple wished to continued the pregnancy and a decision to accept was taken after having consulted the avaible literature. The preterm labour, at 34 weeks with cesarian section, resulted in the livebirth of a healthy female infant (Apgar 9-10).
No persistent gestational trophoblastic neoplasia was observed during the follow-up at 6 months. Hydatiform mole with a live fetus is a rare obstetric occurrence. In the case of a normal fetal karyotipe, it is justifiable to await developments in the absence of maternal complications. However, treatment criteria still need improvement and diligent maternal follow-up is always warranted in the postpartum period.

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