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A Journal on Internal Medicine and Pharmacology

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2013 May;172(5):351-60

language: English

Endovascular treatment of femoropopliteal occlusive disease: percutaneous transluminal angioplasty or stenting?

Strati T. M. 1, Chrysaidou A. 1, Sarlis P. 1, Papadimitriou D. 2

1 Postgraduate Education in Medical Research Methodology, Medical SchoolAristotle University of Thessaloniki, Thessaloniki, Greece;
2 Vascular Unit, 2nd Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece


Endovascular treatment is an established modality of femoropopliteal occlusive disease. However, there are conflicting results concerning the choice of applying percutaneous transluminal angioplasty (PTA) or stenting (ST). Aim of this study, is the systematic review of the most recent studies in the international references where the results of the two methods are compared, in order to determine, using standard evidence based criteria, the safety and effectiveness of the two methods. Screening of the database Medline/PubMed and Cochrane, covering the period between January 1999 to December 2010 with additional literature search of the references of the articles was done in order to discover the studies that deal with the subject of this systematic review. The investigation was limited in meta-analysis and either randomized or not controlled trials. The critical evaluation of the studies was performed according to the Impact factor of the Journal on which they were published. Sixteen studies were considered to be appropriate and linked to the quest of this review. Three meta-analysis, twelve randomized controlled trials and one cohort studies were finally included. Great disagreement exists as regards to the choice of percutaneous transluminal angioplasty versus stenting in the treatment of this specific vascular disease because of either its complicated background or the technological eruption of new techniques and materials. Unfortunately, recent studies failed to extract lucid answers. There is a clear need for new, well designed, with more participants trials to establish the potential benefit of each method.

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