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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 December;171(6):767-73

language: English

Does aerobic exercise effect on the levels of interlukin-6, TNF-α and plasma CRP in the elderly women?

Taghian F. 1, Rahnama N. 1, 2, Esfarjani F. 2, Sharifi G. R. 1

1 Department of Physical Education and Sports Sciences, Islamic Azad University, Khorasgan (Isfahan) Branch, Isfahan, Iran;
2 Department of Physical Education and Sports Sciences, University of Isfahan, Isfahan, Iran


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AIM: Physical activity inversely associated with inflammatory markers. Active old people as compared with non-active have the lower level of IL-6, TNF-α and CRP. The purpose of this study was to determine the effect of 12 weeks of aerobic exercises on inflammatory markers in elderly women (75-60 old years).
METHODS: Twenty old women were chosen and then randomly were divided into two groups; control (mean±SD, age 68 ± 4 years, height 1/55±0/4 m, weight 72/67 ± 14/62 kg) and experimental (age 69 ± 3 years, height 1.56±0/5 m, body weight 68/36 ± 15/90 kg). Weight, body fat percent and waist to hip ratio were assessed by the body composition analyzer. The inflammatory markers IL – 6, TNF-α and CRP were measured before and after aerobic exercise program (walking three sessions per week, for 3 months) by ELIZA. Paired t-test and analysis of covariance was used to analyze the data.
RESULTS: Significant reduction was observed in body weight (68 vs. 64 kg), fat percent (38 vs. 35%), body mass index (28 vs. 26) and waist to hip ratio (1/02 vs. 1/01) in experimental group after the training period (P<0.05). But no significant difference was found for control group in these variables (P>0.05). Following training modality TNF-α and CRP levels decreased significantly (P<0.05), but no change was observed in IL-6 (P>0.05). No significant changes were found for the control group in inflammation markers (P>0.05). It can be concluded that aerobic training would be recommended as an appropriate modality for the elderly women for improving their health and reducing cardiovascular risk factors.

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