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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Brenes J. 1, King R. 2, Irfanullah A. 3
1 Hennepin County Medical Center, Minneapolis, MN, USA;
2 University of Minnesota, Minneapolis, MN, USA;
3 Hennepin County Medical Center, Minneapolis, MN, USA
Congenital venous malformations are estimated to have a prevalence of 1% in the general population, and most of these involve the inferior vena cava (IVC). The fetal IVC develops after a complex process that involves the interaction of three primitive pairs of veins. We present 3 first-degree relatives, all whom presented with back pain, lower extremity edema and bilateral iliofemoral thrombosis. All 3 had different degrees of hypoplasia of the inferior vena cava documented by CT scan. Hypercoagulable workup revealed lupus anticoagulant antibodies in 2. All were succesfully treated with catheter directed thrombolysis and anticoagulation. To our knowledge, this is the first report of a familial series of patients presenting with IVC malformations and deep venous thrombosis (DVT). It underscores the importance of these anomalies as a risk factor for DVT, which should be suspected in young patients, those with iliofemoral thrombosis or bilateral involvement. The pertinent literature is reviewed.