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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 June;171(3):287-93
Evaluation of diagnosis efficiency of exfoliative cytology in pre-malignant and malignant lesions of the mouth
Evangelista Bagateli J. C. 1, Veltrini V. C. 2, Kamei N. C. 2
1 State University of Maringá (PGO-UEM), Paraná, Brazil;
2 Laboratory of Oral Pathology, State University of Maringá (UEM) and University Center of Maringá, Paraná, Brazil
Aim. This study evaluated the diagnosis efficiency of exfoliative cytology, comparatively to biopsy, in pre-malignant and malignant lesions of the mouth.
Methods. Smears were obtained from 17 lesions with clinical features which suggest this diagnosis, using metal spatula number 24, and, in a same surgical moment, biopsies of these lesions were performed. Then, the results of both techniques were compared.
Results. For premalignant lesions, there were 63.6% of agreement between the analyzed techniques, 9.1% of false-positive and 27.3% of false-negative results for exfoliative cytology. For malignant lesions, the exfoliative cytology got 50% of correct diagnosis and 50% of fase-negative results. Considering all lesions, the results of cytological technique were satisfactory in 60% of the cases, achieving 6.7% of false-positive and 33.3% of false-negative results.
Conclusion. It was concluded that exfoliative cytology is fairly efficient in attributing the degree of epithelial dysplasia to pre-malignant lesions; however being unable to offer absolute reliability in the diagnosis of oral cancer. It is important to perform the cytological technique correctly, to avoid that eventual mistakes damage the diagnosis.