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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 April;171(2):237-9
A rare complication due to propylthiouracil use: lupus-like syndrome
Gul O. O., Unal O. K., Cander S., Tuncel E., Imamoglu S.
Department of Endocrinology and Metabolism, Uludag University Medical School, Bursa, Turkey
Propylthiouracil and methimazole are frequently used in the management of hyperthyroidism. A 36 year old female patient with toxic multinodular goiter, developed polyarthralgia, neutropenia, hypergammaglobulinemia, and microscopic hematuria after treatment with propylthiouracil (PTU). Antinuclear antibody (ANA) was positive whereas anti-double stranded DNA, antihistone antibody were negative. PTU was discontinued and all symptoms subsided gradually. All these findings suggest that she developed a PTU-induced lupus-like syndrome.