Home > Journals > Gazzetta Medica Italiana Archivio per le Scienze Mediche > Past Issues > Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 April;171(2) > Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 April;171(2):109-21





A Journal on Internal Medicine and Pharmacology

Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index



Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 April;171(2):109-21

language: English

Intervention of high-temperature aerobic exercise on lipid metabolism and expression regulation of adipocyte differentiation genes in high- fat- diet- fed rats

Weilin L. 1, Peng H. 1, Guo L. 1, Jiaqin C. 1, Chimiao L. 2, Hua Y. 2

1 Department of Physical Education, Hunan Normal University, Changsha, People’s Republic of China;
2 The Central Hospital of Shaoyang, Shaoyang, People’s Republic of China


Aim. Effect of free radical lipid metabolism and expression of visceral white adipose tissue TNF-α, Leptin, PPARγ, visfatin mRNA by high temperature aerobic exercise in high-fat-diet-fed rats.
Methods: After 8 weeks of high fat fed rats, all rats were randomly divided into Exercise group in high temperature (35°C), Exercise group in normal temperature (23°C), and Non-exercise control group, of which runs on the platform at medium tenacity in 45min each single day in 8 weeks on end. In this study, adopted automatic clinical chemistry analyzer and enzyme linked immunosorbent assay to detect biochemistry indexes, and method of RT-PCR to detect expression of genes.
Results. “Lee” index in high-fat-diet-fed rats rose obviously after 8 weeks (p<0.01), while 8 weeks passed, ”Lee” index in HE group dropped rapidly as a whole (p<0.01). Content of TC, TG and LDL-C in blood plasma in HE group dropped faster than that in HC group, while content of HDL-C rose (p<0.05); content of TG and LDL-C in HE group is lower than that in NE, while content of HDL-C is relatively high (p<0.05); but content of TC has no significance (p>0.05). With NE group, content of LPL in HE group has a tendency of rising but significance difference (p>0.05), while content of ApoA rose obviously (p<0.01). HE group SOD was significantly higher than NE group, while MDA was significantly decreased (P <0.01). Expression of Leptin mRNA, PPARγ and mRNA in HE group is obviously higher than that in NE group, while expression of TNF-αmRNA and visfatin mRNA decreased.
Conclusion. Aerobic exercise for 8 weeks have improved effectively caused disorder of lipid metabolism in high- fat- diet- fed rats, promoted activity of lipids metabolic enzymes, increased content of lipid transport protein, boosted ability of body against oxygen radicals; aerobic exercise in high temperature has different expression of between differential genes in Adipose tissue, restrained and promoted, which possibly provides a good physical basis for up-expression, a expression good for lipid metabolism, of some regulator genes, thus in turn curbs adventure and development of chronic cardiovascular disease.

top of page

Publication History

Cite this article as

Corresponding author e-mail