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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 February;171(1):65-7

language: English

Potential novel preventive effect of taurine versus keloid formation

Fallahzadeh M. A. 1, Mahdavi D. 2, Fallahzadeh M. K. 3, Namazi M. R. 4

1 Shiraz Nephro-urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Psychology, University of British Columbia, Vancouver, Canada
3 Shiraz Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4 Shiraz Skin Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


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Keloids are benign dermal tumors that form due to dysregulation of wound healing after dermal injury with exuberant local fibroblast proliferation and collagen production. TGF-β, a potent profibrotic cytokine, plays an essential role in formation of keloids. Furthermore, activation of NF-κB pathway, by inducing the production of proinflammatory mediators such as IL-6 and NO and also by inhibiting the apoptosis of local fibroblasts, is considered to significantly contribute to the pathogenesis of keloid formation. Taurine is a semi-essential aminoacid with strong antioxidant, anti-inflammatory and anti-fibrotic properties. We suggest that by inhibiting the production of TGF-β and hampering the activation of NF-κB pathway, taurine may be a novel and effective treatment for prevention of keloid formation.

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