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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 February;171(1):1-5
Impairments on the mechanical properties of rat anterior cruciate ligament after intra-articular injection of corticosteroid: short-term results
Okubo R., Zamarioli A., Falcai M. J., Volpon J. B., Shimano A. C.
Laboratory of Bioenginnering, Department of Biomechanics, Medicine and Rehabilitation of Locomotor Apparatus School of Medicine, University of Sao Paulo Ribeirao Preto, Brazil
aim. The purpose of this study was to investigate the effects of an intraarticular administered corticosteroid on the mechanical properties of anterior cruciate ligament (ACL) in rats and to examine the time duration of corticosteroid effects post-application.
Methods. Twenty-five male Wistar rats weighed approximately 250g were randomly assigned into five groups: (1) control; (2) sham: saline injection; (3) one week corticosteroid: one application of corticosteroid and further analysis one week post-injection; (4) two weeks corticosteroid: one application of corticosteroid and further analysis two weeks post-injection and (5) one and two weeks corticosteroid: two applications of corticosteroid, one per week, and further analysis two weeks post first injection. Corticosteroids were injected without anaesthesia administration into the knee joint of the animals from groups 3 to 5 using dexamethasone phosphate – Dexagil in a dosage of 0.1 mL. The knees were dissected in order to expose the ACL and its fixations on femur and tibia. ACL was submitted to mechanical test for evaluating the ultimate load and stiffness.
Results. Data showed that the mechanical strength of ACL was lower in animals treated with corticosteroid.
Conclusion. Administration of corticosteroid in articular cavity provides a short-term deleterious effect on the mechanical properties of the anterior cruciate ligament.