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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2011 December;170(6):425-31
Ambulatory activity: indicator of changes in skeletal muscle functional capability in the elderly
Kaasik P. 1, Aru M. 1, Alev K. 1, Pehme A. 2, Sagim J. 1, Seene T. 1
1 Institute of Exercise Biology and Physiotherapy, University of Tartu, Tartu, Estonia
2 Institute of Sport Pedagogy and Coaching, University of Tartu, Tartu, Estonia
Aim. Aim of this study was to examine the possibilities to assess the development of sarcopenia and glucocorticoid caused myopathy according to changes in ambulatory activity monitoring results.
Methods. 48 Wistar rats, 16-week-old and 120-week-old, received dexamethasone intraperitoneally 100 mg/ 100 g body mass during 10 days. Ambulatory activity, muscle strength, sarcopenia, degradation and synthesis rate of myofibrillar protein were registered. The Pearson correlation coefficient was used as a characteristic of association and the analysis was performed using software R version 2.6.1 and MS Excel.
Results. Results of this study show that ambulatory activity monitoring is a reliable indicator for loss of muscle mass during ageing and glucocorticoid caused myopathy as a result of increased protein degradation and a decreased synthesis rate. Loss of muscle mass in aged subjects is in good agreement with decreased muscle strength. Loss of muscle mass, particularly contractile proteins as a result of increased destruction of myofibrillar machinery and decreased protein synthesis are leading to the decrease of muscle strength. Loss of muscle strength is the indicator of the decrease in life quality during ageing and muscle deseases.
Conclusion. The present study shows that molecular changes in the contractile apparatus reflect on the ambulatory activity level and indicate changes in the functional state of skeletal muscle contractile apparatus. This knowledge may be important and useful in rehabilitation and preventive medicine.