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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2011 December;170(6):397-403
Acute effect of omega-3 polyunsaturated fatty acids on muscle lesion and inflammation markers in rats subjected to resistive exercises
Pereira Coqueiro D. 1, Cincotto Dos Santos Bueno P. 2, De Jesus Simões M. 3
1 Center for Experimentation in Animal Models, University of Marilia, Marilia, Brazil
2 Center for Experimentation in Animal Models, University of Marilia, Marilia, Brazil
3 Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil
Aim. The purpose of this study was to evaluate the acute effect of ingested omega-3 polyunsaturated fatty acids on muscle lesion markers (creatine kinase and lactate dehydrogenase) and an inflammation marker (C-reactive protein) in a resistive exercise session.
Methods. Thirty-one Wistar male rats, about 260g each, were divided into 4 groups: G1-control (n=8); G2-supplementation before the exercise (n=8); G3-supplementation after the exercise (n=8); G4-exercise without supplementation (n=7). The exercise protocol was made up of 4 series of 10 jumps each with a 60-second interval between series in only one resistive exercise session with a 50% load of body weight. The animals ingested 3g of omega-3 by gavage. Forty-eight hours later the animals were euthanized, and their blood collected and subsequently analyzed. The CK concentrations increased significantly in G2 (555 ± 238) in comparison with G1 (248±100). The same happened with LDH: G2 (1261 ± 466) and G1 (585 ± 368). The G4 mean (1679 ± 472) was high and well over the G1 and G3 means (906 ± 353).
Results. There was a significant increase in CRP in G4 (0.054 ± 0.043), the group subjected to the resistive exercise, in comparison with G1 (0,018±0,005), the group that did no exercises, and G3 (0,018±0,007), the group that received supplementation after the exercise. The G3 and G1 values remained similar.
Conclusion. In short, acute ingestion of omega-3 after the exercise effectively decreased the muscle lesion markers (CK and LDH) and the response marker of the acute inflammatory phase (CRP).