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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2011 October;170(5):293-300
Follow-up of patients with cured Hodgkin’s lymphoma
Miltényi Z. 1, Székely G. 2, Végh J. 1, Váróczy L. 1, Simon Z. 1, Gergely L. 1, Illés Á. 1
1 3rd Department of Internal Medicine, Institute for Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
2 State Health Centre Budapest, Budapest, Hungary
AIM:The knowledge about complications following the treatment of patients with Hodgkin’s lymphoma (HL) as well as early recognition and treatment of its complications have been gaining more and more importance since vast majority of patients survive long or are cured.
METHODS: Late complications of 123 cured HL patients were examined who received treatment between 1974 and 1998.
RESULTS:Mean age was 31.9 years at the time of diagnosis, while mean survival after diagnosis was 18.8 years. 101 of them are still alive, and we have no data about nine patients. Changes in thyroid functions, mainly hypothyroidism, could be detected in approximately third of the patients. Second common complication was cardiovascular system damage (26.89%). Pulmonary and pleural damage was found in 13% of patients. Less frequently, secondary neoplasms (12.2%), injury of skeletal and muscular systems (6.5%) and damage of the genitourinary system (5.7%) were observed. 146 patients died, of which over 50% was attributed to lymphoma. After 15th year from diagnosis, deaths caused by lymphoma were not observed.
CONCLUSION:Owing to treatment according to up-to-date therapeutic principles, number of long surviving patients has been on the rise. They rarely present at haematological care units years or even decades after treatment. It’s important for both primary care providers and specialists of various medical fields to be familiar with such complications and importance of various screening tests since early recognition and management of complications can contribute to improvement of patients’ quality of life and reduction of mortality associated with late complications.