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A Journal on Internal Medicine and Pharmacology

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2011 October;170(5):285-92

language: English

History of a research: a theory concerning the sterols

Rivara G.

San Giovanni Battista Hospital, Turin, Italy


AIM: This is summarized notice of a research that deals with the study of cell metabolism and its disorders, in particular with the growth of embryos and the process of cell differentiation (the reverse mechanism of tumor formation). Starting from the hypothesis that sterols could be the substances capable of regulating the embryonic growth, and so that they could be a turning point in cancer therapy, the research began trying to understand active behaviour of phytosterols.
METHODS:After choosing certain types of plant sterols and then proceeding with their esterification and coemulgation, the studies concentrated on the behaviour of several types of cancer cell cultures treated with different types of sterols ester. Experiments were also made on small animals, and the in vitro research has been extended to the study of some forms of cancer related to viral infections such as HIV.
RESULTS: After evidence of the penetration of the substances both in the cytoplasm and into the nucleus of cancer cells, tests on mice inoculated in the subcutaneous tissue with the TSA type of breast cancer, obtained 37% of total cure in the treated mice. Also histological examination of human lung cancer cells, that have been transplanted subcutaneously to treated mice, revealed a widespread apoptosis of the cancer cells. The studies on viral infections revealed that the steroid preparations inhibited the action of the virus only in the viral infections that may cause the formation of a cancer.
CONCLUSION: After a few years the research has been interrupted and it was allowed to publish only in part. Nowadays it would be worthwhile to encourage the research concerning the differentiation of embryonic cells involving the chains of steroids.

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