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A Journal on Internal Medicine and Pharmacology

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2011 April;170(2):83-92

language: English

Exercise preconditioning alleviates cardiopulmonary damage during endotoxemia

Shao D.-Z., Chang C.-N., Chen Y.-C., Chen Yu-Wen, Hung C.-H.

1 Department of Cosmetics Application and Management, Chung Hwa University of Medical Technology, Tainan, Taiwan
2 Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan
3 Division of Physical Therapy, Department of Physical Medicine and Rehabilitation, Cheng Hsin Rehabilitation Medical Center,Taipei, Taiwan
4 Department of Physical Therapy and Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan


Aim. During endotoxemia, inflammatory responses were induced and results in cardiopulmonary dysfunction. However, heat shock protein 72 (HSP72) which is found after exercise can protect the cardiopulmonary system from lethal damage. Therefore, our hypothesis was that exercise-trained rats could increase the expression of HSP72 in heart and lung to attenuate cardiopulmonary damage during endotoxemia.
Methods. Male Wistar rats were separated into sedentary and exercise groups. The exercise group was trained to run on the treadmill 30-60 minutes/day at 1.0 mile/hr, 5 days/week for three weeks. Twenty-four hours after the last training session, we compared the temporal profiles of hemodynamic parameters in urethane-anesthetized rats receiving an injection of lipopolysaccharide (LPS). We also determined arterial blood gas, lung injury, tumor necrosis factor-alpha (TNF-α) level in serum and bronchoalveolar lavage. In addition, HSP72 expression in the heart and lung were determined.
Results. We found a significant increase in all hemodynamic data, decreased serum and lavage TNF-α level, and reduced lung edema in the exercise group compared to the non-exercise group during endotoxemia. HSP72 expression in heart and lung was significantly increased in exercised rats.
Conclusion. Exercise training can attenuate the occurrence of inflammatory responses and alleviate cardiopulmonary damage to increase survival rate during endotoxemia.

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