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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Behnam B. 1, Sadat Hashemi S. M. 2, Nesari Rad Motlagh M. 3, Sheikhvatan M. 4
1 Psychiatry, Semnan University of Medical Sciences, Semnan, Iran;
2 Biostatistics, Semnan University of Medical Sciences, Semnan, Iran;
3 Semnan University of Medical Sciences, Semnan, Iran;
4 Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
Aim. Despite confirmation of adverse effects of depressive disorders on diabetes-related health outcomes, relationship between depression and poor glycemic control is already questioned. The goal of this study was to examine this relationship in a sample of Iranian diabetic population.
Methods. One hundred and ninety eight consecutive adult primary care patients aged >30 years with the diagnosis of type 2 diabetes mellitus referred to diabetes clinic at the Fatemieh hospital in Semnan, Iran were studied. HbA1c was determined using ion exchange high performance liquid chromatography certified by the National Glycohemoglobin Standardization Program. The severity of depressive symptoms was also measured using the 21-item the Beck Depression Inventory (BDI) validated among Iranian population.
Results. Overall depression rate in our diabetic patients was 71.7% that 17.7% of them suffered from severe to very severe depressive symptoms. There was a strong relationship between depression severity and HbA1c level (P<0.001) so that 84% of those without depression had HbA1c level <7%, whereas all 12 patients with very severe depression symptoms had HbA1c level >7%. Relationship between the severity of major depression and glycemic control level was independent to patients’ gender and age.
Conclusion. Level of glycemic control has a pivotal role for predicting depressive symptoms severity. Thus, pharmacological monitoring of depressive symptoms in diabetic patients and their participating in psychological consultation and therapeutic sessions for prevention of depression adverse effects are recommended.