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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2010 August;169(4):137-48
Visfatin genotype may influence the effects of green tea extract (Camellia sinensis) in Type 2 diabetes patients. Double blind placebo-controlled clinical trial study
Mirzaei K., Hosseinzadeh-Attar M. J., Hossein-Nezhad A., Karimi M., Kamalinejad M., Jafari N., Najmafshar A., Karimi F., Eshraghian M. R., Mohammadzadeh N., Larijani B.
1 Department of Nutrition and Biochemistry, school of Public Health and Institute of Public Health Tesearch, Tehran University of Medical Sciences, Tehran, Iran
2 Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Traditional Medicine Department, Faculty of Tradition Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 Department of pharmacognosy+Faculty of pharmacology, Shahid Beheshtei University, Tehran, Iran.
5 Social Support Organization, Tehran, Iran
6 Department of Epidemiology and Statistic
Faculty of Public Health
Tehran University of Medical Sciences
Aim. The aim of current study is to assess the effect of green tea extract (GTE) on type2 diabetes mellitus (T2DM) management according to visfatin gene promoter region (-4689G/T) that registered in NCBI as SNP rs2110385. It was located in Chromosome 7(7q22.2).
Methods. Totally 102 T2DM patients with stratified randomized method were split into interventional and control groups in double blind placebo-controlled clinical trial. GTE, 500mg, and placebo were given for 8 weeks. Laboratory and anthropometric measurements included fasting serum glucose, oral glucose tolerance test (OGTT), HbA1C and lipid profile, fasting serum Visfatin, adiponetin, insulin, BMI and WHR were measured. Genotyping for SNP was performed by using the RFLP-PCR method.
Results. Triglyceride, LDL cholesterol levels were decreased significantly in GTE treated group with TT genotypes (Pvalue<0.01). Also regarding to GG genotype, only total cholesterol had significant reduction after treatment episode in GTE group (Pvalue<0.05). We showed a significant decrease in HbA1C and increase in visfatin levels in GTE group after intervention too (Pvalue equal 0.05 and 0.03 respectively). Our findings showed no significant difference in variation in control group after intervention time.
Conclusions. Visfatin genotypes may modify the effect of Green tea extract on lipid profile through different levels of visfatin expression .Clearly, further studies are necessary to clarify the function of visfatin and its genotypes in GTE treatment.