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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2009 April;168(2):95-100

language: English

Genetic variation in D-loop region of mitochondrial DNA in judoists and its association with iron metabolism

Jung I. G., Oh S. D., Kim E. J., Kang B. Y.

College of Physical Education Hanyang University Seoul, Korea


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Aim. The purpose of this study was to compare the difference in distribution of the genetic polymorphism within the D-loop region of mtDNA in controls and judoists, and to investigate the relationship between this polymorphism and iron parameters in both groups.
Methods. A total of 117 male subjects including 57 controls and 60 judoists were selected for this study. The C to A polymorphism of mtDNA was analyzed by PCR-KpnI restriction digestion method, and biochemical parameters measured by autoanalyzer.
Results. The allele distribution of this polymorphism was 75.9% and 24.1% for C and A alleles, respectively, and similar between controls and judoists, respectively. With respect to iron parameters, this polymorphism was not significantly associated with any iron parameters studied in our subjects(P>0.05)
Conclusion. In conclusion, our results suggest that this genetic polymorphism of D-loop region in mtDNA might not be useful as a genetic marker influencing iron metabolism in our subjects. Further studies using large sample size and other candidate genes will be needed

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