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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2009 April;168(2):81-88
DNA variations of renin-angiotensin system genes in Sasang constitution
Lee S. Y. 1, Kang B. Y. 2
1 Department of Pharmacy Sahmyook University Seoul, Korea
2 College of Physical Education Hanyang University Seoul, Korea
Aim. Sasang Constitutional Medicine is a branch of Oriental Medicine and a Korean Traditional Medicoine that includes four physical characteristics such as Taeumin, Taeyangin, Soyangin and Soumin. Nowadays, several study groups have been interested in genetic factors of Sasang constitution, and investigated the relationship between Sasang constitution and some candidate genes including HLA system and Angiotensin I converting enzyme (ACE) gene, but no precise relationship between these candidate genes and Sasang constitution has yet been established.
Methods. To estimate the relationship between genetic components (angiotensinogen, ACE and angiotensin II type1 receptor genes) of RAS and Sasang constitution, we performed the association studies using gene polymorphisms as genetic markers for total 99 Korean subjects (Taeyang, 3 cases; Taeum, 25 cases; Soyang 41 cases; Soeum 30 cases). Genotype distributions of each candidate gene were determined by PCR-RFLP and agarose gel electrophoresis methods.
Results. There were no significant differences in genotype frequencies of three candidate genes among each group (P > 0.05). However, the genotype frequencies of three candidate genes were similar to the data from other Asian population, but considerably different from those of Caucasian and African populations.
Conclusion. In conclusion, our data suggest that the genetic polymorphisms in the RAS gene might not be useful as a genetic marker to differentiate each constitution stratified by Sasang constitution. Further studies using large sample size and other ethnic groups will be required.