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CURRENT ISSUEGAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index

 

Gazzetta Medica Italiana Archivio per le Scienze Mediche 2009 February;168(1):1-6

 ORIGINAL ARTICLES

Minor changes in haemoglobin concentration significantly correlate with oxidative stress

Hamidi-Alamdari D. 1, Reza-Parizadeh M. 2, Varasteh A. 3, Bonakdaran S. 4, Honarmand M. 5, Sarrafnejad A. 6, Topouridou K. 1, Paletas K. 7, Pegiou T. 1, Koliakos G. 1

1 Department of Biological ChemistryMedical School, Aristotle University of Thessaloniki Thessaloniki, Greece
2 Department of Nutrition and Biochemistry Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Immunobiochemistry Laboratory Immunology research Center Avicenna Research Institute Mashhad University of Medical Science
Mashhad, Iran
4 Endocrinology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Pediatrics, School of Medicine, University of Tehran, Tehran, Iran
6 Department of Immunology, School of Medicine, University of Tehran, Tehran, Iran
7 Laboratory for the Study of Metabolic Diseases, B Medical Clinic, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Aim. Low haemoglobin (Hb) concentration (anaemia) is a risk factor for cardiovascular disease (CVD). Recently, oxidative stress (OS) has been considered as a significant risk factor for CVD and the unifying mechanism for many cardiovascular risk factors. The aim of this study was to find whether there is any correlation between mild anaemia and oxidative stress.
Methods. One hundred and forty four individuals were included in this study. Sixty one were patients with type 2 diabetes, 21 haemodialysis patients, and 62 healthy volunteers. Oxidative stress was estimated by the measurement of Prooxidant Antioxidant Balance (PAB) using a previously evaluated assay. Total Hb concentration was measured by a Sysmex XE-21000 haematology analyzer.
Results. A significant inverse correlation bet-ween OS and Hb was established in diabetic and dialysis patients. A marginally significant negative correlation was found between OS and Hb in healthy volunteers. As was expected OS was significantly higher in haemodialysis than in diabetic patients than in healthy volunteers.
Conclusion. An interrelation between OS and total Hb concentrations that is more prominent in patients with high oxidative stress has been observed for the first time.

language: English


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