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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2008 December;167(6):267-73

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

The distribution of haptoglobin polymorphism in University judo players and its association with several hematological parameters

Jung I. G., Oh S. D., Hwang Y. J., Kang B. Y.

College of Physical Education Hanyang University, Seoul, Korea


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Aim. Athletes compared to persons of general population shows the higher prevalcence of iron deficiency, but the reason for this phenomenon has clearly not been elucidated. Because iron metabolism is influenced by multiple environmental and genetic factors, and haptoglobin is one of components associated with iron metabolism, genetic variation encoding for this protein may be a good candidate to analyze the relationship between genetic predisposition and iron parameters in athletes. Thus, the purpose of this study was to investigate the difference in distribution of haptoglobin polymorphism in controls and judo players as athletes, and the relationship between this polymorphism and iron parameters in both groups.
Methods. A total of 50 male subjects including 25 controls and 25 judo players were selected for this study, and biochemical and genetic analyses from them performed. Results. There were no significant differences in genotype and allele frequencies in haptoglobin polymorphism between two groups, respectively. However, this polymorphism was significantly associated with serum haptoglobin concentration irrespective of athletic condition (P<0.05).
Conclusion. In summary, our results suggest that haptoglobin polymorphism might be one of genetic factors that determine the phenotypic variance of serum haptoglobin level in the both male controls and judo players.

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