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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2008 October;167(5):221-9
The effect of continuous training on C-reactive protein of wistar14848 rats
Gaeini A. 1, Rahnama N. 2, Dabidi Roshan V. 3
1 Faculty of Physical Education University of Tehran, Tehran, Iran
2 Department of Physical Education and Sport Science University of Isfahan, Isfahan, Iran
3 Faculty of Physical Education, Mazandaran University, Mazandaran, Iran
Aim. This study was designed to investigate the effect of continuous training on C-reactive protein (CRP), which is the most sensitive inflammatory marker for predicting of cardiovascular disease.
Methods. This study was conducted on obese, female wistar14848 rats (325.6±4.93 g and 21 months old). A pilot study was carried out to investigate the difference in CRP between the obese (226.75±5.12 g and 4 months old) and thin (168.13±5.6 g and 4 months old) young rats, and also between the obese (325.6±4.93 g and 21 months old) and thin (246.87±4.79 g and 21 months old) rats (each group included 8 rats). Then, 32 rats were divided randomly into control and experimental groups and in each group the related sub-groups were chosen randomly. An experimental training programme was carried out for five days a week at a definite treadmill speed for 12 weeks. Blood samples were drawn at three phases of pre-training, mid-training and post-training. High-sensitivity CRP was measured with an immunoturbidimetric method.
Results. Repeated-measures ANOVA showed that the reduction in CRP levels was not significant (P=0/08) in the first six weeks but CRP decreased significantly (P<0.0001) after 12 weeks.
Conclusion. It can be concluded that the decline in this inflammatory marker after a period of continuous training attenuated the atherogenesis process.