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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2008 October;167(5):205-12

language: Italian

Mud pack treatment of osteoarthritis patients: changes in serum levels of cartilage disease markers

Bellometti S. 1, Tassoni T. 2, Gregotti C. 1, Richelmi P. 1

1 Scuola di Specializzazione in Idrologia Medica Dipartimento di Medicina Interna Facoltà di Medicina Università degli Studi di Pavia, Pavia, Italia
2 Dipartimento di Biologia Facoltà di Scienze Naturali Università degli Studi di Padova, Padova, Italia


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Aim. The current therapy of osteoarthrosis (OA) is largely focused on decreasing pain and non steroidal anti-inflammatory drugs (NSAID)is the most common pharmacological treatment. In order to reduce drug dose and side-effects, innovative approaches are required to treat OA. Aim of the present study was to investigate if treatment with thermal mud pack, moor pack or paraffin pack affect markers of inflammation and cartilage metabolism such as IGF I, TNFα, IL 1, PGE2 in OA patients.
Methods. Eighty OA patients were randomised in 4 groups: group A (paraffin packs) , group B (moor packs), group C (thermal mud packs), group D (control group-no treatment). Blood samples were collected before and after the treatments to assay IGF I, TNFα, IL 1, PGE2 serum levels.
Results. IGF I values significantly increased in group A and of PGE2 values in groups A and B, indicating adverse effects of the treatments. The decrease of TNFα, IL 1, PGE2 in group C might indicate a decreased intensity of inflammation.
Conclusion. The results show that whole body thermal mud packs producing short term effects on OA chemical markers may be used as an effective alternative/integrative approach to the traditional pharmacological treatment of OA disease.

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