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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Dirigente Medico I livello, Struttura Complessa Chirurgia Generale, Regione Piemonte, ASL 13, Presidio Ospedaliero di Borgomanero, Novara
Aim. One of the most frequent disfigurements caused by fibrosclerotic adipose panniculopathy (cellulitis) is the annoying problem of telangiectasias, the most superficial and visible expression of malfunctioning of the microcirculation, lymphatic stasis and hydric retention. The most practised treatment today is sclerotherapy but there remains the problem of recurrent telangiectasias in the treated cutaneous areas and in new areas affected by cellulitis. With a view to finding an effective prevention of recurrent telangiectasias after sclerotherapy, our attention has been drawn to purified Diosmin, a natural bioflavonoid obtained from rue-extracted esperidine, widely used in medicinal specialities for its vasotonic, anti-inflammatory, antiedemigenous and vasoconstrictor activity.
Methods. We therefore selected 30 women with moderately severe cellulitis, subjected them to sclerosing treatment for telangiectasias in the two prior weeks, and followed them up for 12 months. All were prescribed a training schedule to be carried out at home or in a fitness centre for a minimum of twice a week (physiotherapy); in a group of 15 women treatment with monthly cycles of Diosmin for 14 days was added (Diosmin, Alfa Wassermann, one 450 mg tablet twice a day), while the other 15 were left without pharmacological treatment.
Results. The results of the study highlighted significant activity of purified Diosmin in the prevention of telangiectasic recurrences; at the end of follow-up, telangiectasias recurred in 6 of the 15 women not treated (40.0%), and in only one of those treated cyclically with purified Diosmin (6.67%), with a statistically significant inter-group difference. Diosmin also proved to be extremely effective in restoring the subcutaneous circulatory microflow and in reabsorbing interstitial edemas and in the recovery of cutaneous and subcutaneous trophism, as testified by the reduction in thigh circumference and by the increase in skin elasticity and softness and in the microcirculation. Photographic examination provided visual confirmation of the results obtained with Diosmin.
Conclusions. In conclusion, our results confirm the usefulness and effectiveness of treatment with Diosmin in women with initial stage moderate cellulitis, with particular reference to the prevention of recurrent telangiectasias following capillary sclerotherapy intervention.