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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2007 August;166(4):121-6
Randomized clinical trial on the use of a new molecule, formulated in suppositories, in the treatment of acute hemorrhoidal disease
Chirurgo Proctologo, Responsabile Servizio Autonomo di Proctologia Chirurgica, Casa di Cura Villa Igea, Acqui Terme (AL)
Aim. To value the efficacy of a new molecole, formulated in suppositories, the beclomethasone dipropionate, in the treatment of acute hemorrhoidal disease.
Methods. We have been recruited 240 patients and divided in 3 parallel groups: the first treated with beclomethasone dipropionate, the second with zinc oxide and bismuth and the third with suppositories of hamamelis/hippocastanum/collinsonia.
Results. The pattern of posology has been of a suppository twice day for 45 days. The patients have been valued after 10, 25 and 45 days after the beginning of the treatment, testing clinical signs (bleeding, mucous erythema, thrombosis) and subjective symptoms (itching, pain, tenesmus).
Conclusion. In our study the beclomethasone dipropionate has been quickly efficacious whether on clinical signs or subjective symptoms, with better surprising results on other two tested products. The beclomethasone dipropionate demonstrated excellent tolerability and never collateral effect occurred. Therefore we believe the new molecule, formulated in suppositories, can be very useful for the specialist physician in proctology for the treatment of the acute hemorrhoidal disease.