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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Nasri H. 1, Baradaran A. 2
1 Hemodialysis Section, Hajar Medical, Educational and Therapeutic Center, Shahrekord University of Medical Sciences, Shahrekord, Iran;
2 Department of Biochemistry, Center of Research and Reference, Laboratory of Iran, Hospital Bu Ali, Tehran, Iran
Aim. To elucidate whether and how in patients with uremia on maintenance hemodialysis, the infection of H. pylori influenced by serum Serum 25-hydroxy vitamin D concentration.
Methods. The study was conducted on patients with end-stage renal disease, who were undergoing maintenance hemodialysis treatment. Serum 25-hydroxy vitamin D (25OH Vitamin D) level and serum helicobacter pylori specific IgG antibody titers were measured through enzyme-linked immunosorbent assay (ELISA) method.
Results. All patients were 36(f=15 m=21). The mean patient’s age was 47(±17) years. The value of serum 25 OH vitamin D of total HD patients was 10.5±18.7 (median: 3.5) nmol/L. The value of serum helicobacter pylori specific IgG antibody titer of all patients wa 7.7 (±9.9) u/ml (median: 2 u/ml). In this study a significant positive correlation between serum 25OH Vitamin D level with serum H. Pylori specific IgG antibody titer was found (data adjusted for age, URR, duration and doses of dialysis) (r=0.36 p=0.043).
Conclusion. It appears that vitamin D may positively affect the chronic inflammatory status of dialysis patients and may potentiate the immune response in hemodialysis patients and allow them to present the infection which best showed by its positive association with helicobacter pylori infection. Because of this immunomodulating effects, vitamin D analogs may offer new means to control the inflammatory status in ESRD patients.