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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2007 February;166(1):1-8

language: Italian

Role of the biochemical markers of laboratory monitoring the nutritional status of patients undergone artificial nutrition

Cancellieri E. 1, Ferla D. 2, Lupi G. 3, Cazzamalli E. 1, Ballarini S. 1, De Bernardis M. 1, Dossena A. 1, Brambilla L. 2, Montanelli A. 1

1 Laboratorio Analisi Chimico Cliniche, Azienda Ospedaliera Ospedale Maggiore di Crema, Crema, Cremona;
2 Farmacia Ospedaliera, Azienda Ospedaliera Ospedale Maggiore di Crema, Crema, Cremona;
3 Terapia Intensiva e Rianimazione, Azienda Ospedaliera Ospedale Maggiore di Crema, Crema, Cremona


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Aim. Several studies have shown that undernutrition is common among hospitalized patients and it has been associated with increased infectious morbidity, prolonged hospital stay, and increased mortality. Assessment of nutritional status is notoriously difficult: manifestation of malnutrition are varied and do not produce a common clinical or biochemical picture. This article reviews, on the base of collected data, the role of the biochemical markers (prealbumin, albumin, transferrin) in the assessment and management of nutritional status of patients who during hospitalization in intensive care unit required artificial nutritional support.
Methods. We have evalueted the course of nutritional status in 24 critically ill patients undergone parenteral nutrition.
Results. In 15 patients the improvement of the parameter prealbumin is associated to a favorable evolution of the clinical picture; 1 patient is died for infectious disease . Among 8 cases in which a lessening of prealbumin has been recorded, 5 of them have had unfavorable outcome; the remaining 3 cases, with favorable clinical outcome, an insufficient nutrizional support can be assumed.
Conclusion. Generally the improvement of the prealbumin is associated to an improvement of the clinical picture. Any further and useful information is given by the use of albumin and transferrin in order to monitor the course of the nutrizional status during the artificial nutritional support.

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