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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2006 October;165(5):227-9

language: English

Energy change in formation of hemoglobin A1C in hemoglobin C disorders

Wiwanitkit V.

Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand


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Hemoglobin A1C is the nonenzymatic glycated product of the Hb beta-chain at the valine terminal residue. Recently, the nature of energy consuming reaction in formation of HbA1C was reported and this was proposed as an underlying pathophysiology for poor nutritional status, muscle loss, and functional impairment poor control diabetic patients. Here, the author focuses on the energy change in formation of HbA1C in case of Hb C disorder, a common disorder in West Asia. In this work, the author calculated for the required energy for HbA1C per unit in Hb C disorder and found that the required energy range from the most to the least as Hb C disease, Hb C carrier and normal hemoglobin, respectively.

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