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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2006 August;165(4):175-9
Fibronectin and preterm labour
Pizzo A., Ardita F. V., Oteri F., Caruso C., La Spada R., Accardo F. M.
Dipartimento di Scienze Ginecologiche, Ostetriche e Medicina della Riproduzione, Università degli Studi di Messina, Messina
Aim. Premature birth may cause neonatal mortality and morbidity. At present only early diagnosis allow positive results to be obtained by means of suitable medico-surgical treatment. Early diagnosis may be further improved by checking the state of the amnio-chorial membranes. This can be performed by searching for foetal fibronectin (F-FN) present in cervico-vaginal secretions of pregnant women with ruptured or merely detached membranes.
Methods. The immunoenzymatic method used for the determination of F-FN Bedside Foetal Fibronectin Membrane Immunoassay (ADEZA). Cervico-vaginal secretions are treated and filtered through a membrane containing monoclonal antibodies specific for F-FN. The test displays various degrees of positivity. In our study we admitted 64 pregnant women between the 23rd and 36th week of gestation with uterine contractions.
Results. In order to better analyse the specific role of the various risk factors in the induction and realisation of premature birth , the subjects were divided into 5 groups.
Conclusions. From an examination of our case study, there emerges data of significant interest which may help accurately evaluate the role of the various factors responsible for pre-term birth. This would allow early diagnosis of risk and the adoption of suitable prophylactic and therapeutic measures. The test for F-FN allows the state of the ovular membranes to be diagnosed (ruptured, detached, intact).