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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2006 April;165(2):73-8
Purified diosmin, a valuable pharmacological aid in the topical treatment of cellulitis in combination with manual lymph drainage, hydroelectrophoresis and tecar therapy
Ambulatorio MICROS, Divisione di Medicina e Traumatologia dello Sport Modica, Ragusa
Aim. Cellulitis is a dystrophic disorder of the connective tissue associated with the local overproduction of free radicals.
Methods. We wanted to determine whether the addition of an antioxidant compound promoting microcirculation-purified diosmin-could enhance the beneficial effects of topical treatment with modern, established methods such as Dr. Vodder’s manual lymph drainage, hydroelectrophoresis and tecar therapy.
Results. Combined systemic treatment with purified diosmin and topical therapy was found to lead to a marked, rapid improvement in subjective symptoms and the achievement of optimal objective results, as measured by cutaneous ultrasonography. These improvements were maintained at follow-up visits at 2, 4 and 6 months.
Conclusion. Systemic purified diosmin enhances the efficacy of topical treatment through two mechanisms of action: a systemic action on blood vessels and lymphatics, with restoration of normal vascular physiology, and a topical action on the areas involved in the inflammatory process.