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A Journal on Internal Medicine and Pharmacology

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2005 August;164(4):257-62

language: Italian

24-hour ambulatory blood pressure monitoring in smoker and non smoker post-menopuasal women treated with ERT

Driul L., Della Martina M., Plaino L., Stella A., Marchesoni D.

Clinica di Ostetricia e Ginecologia, Policlinico Universitario di Udine, Università degli Studi di Udine, Udine


Aim. Hypertension represents one of the most important risk factors for cardiovascular diseases. Many studies demonstrated an increase of arterial blood pressure in postmenopausal women while in fertile age blood pressure in women is lower than in men. The aim of our study was to evaluate the possible changes of blood pressure values, using a 24-hour ambulatory blood pressure monitoring, in normotensive smoker and no smoker postmenopausal women, submitted to transdermal estrogen replacement therapy.
Methods. A group of normotensive postmenopausal women (n=46) was included in this study and divided in two groups: smokers (n=16) and no smokers (n=30). We analysed 24-hour systolic and diastolic blood pressure and also diurnal and nocturnal blood pressure.
Results. While there were no differences about blood pressure between the two groups, we observed a significant decrease in diurnal dyastolic pressure (p<0.05) and in nocturnal diastolic pressure (p<0.05) in smokers before and after treatment with transdermal estradiol. Moreover, there was a decrease of 24-hour blood pressure in the two groups but it was not statistically significant.
Conclusions. The present data showed that blood pressure decreases in smoker normotensive postmenopausal women while there are no differences in the non smoker group. We supposed that estradiol can lower blood pressure especially in smokers, maybe acting on the synthesis of endothelial factors responsible of the modifications of the vascular tone such as nitric oxide (NO) and endothelin-1 (ET-1).

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