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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Cesarone M. R., Belcaro G., Cornelli U., Di Renzo A., Mucci F., Dugall M., Cacchio M., Cornelli M., Adovasio R., Fano F., Ledda A., Ricci A., Stuard S., Vinciguerra G.
San Valentino-Vasto Vascular Screening Project, Department of Biomedical Sciences, G. D'annunzio University, Chieti, Pescara, Italy
Aim. The aim of this study was to evaluate the efficacy of the use of oral colostrum in the prevention of flu episodes in comparison with anti-flu vaccination and considering as a reference group subjects without prophylaxis. Methods. A group of 144 subjects was included; 137 completed the 3-month follow-up; 7 dropouts were caused by non-medical problems. The groups were comparable (no prophylaxis, vaccination only, colostrum only and colostrum+vaccination).
Results. In subjects treated with colostrum the average number of episodes in each individuals in 2 months (0.335; range 0-3) was significantly lower than the number of episodes registered in non-treated subjects (in the colostrum group there were 25% of the episodes observed in non-treated subjects; P<0.05) and lower than the number observed in the vaccination group (in the colostrum group only 30% of the episodes observed in the vaccination group, not using colostrum was recorded; P<0.05). The difference is significant (P<0.05) both considering the period of 2 months and 3 months after inclusion. The number of days with flu was 3 times higher in the non-colostrum subjects. Costs observed considering loss of working days, treatments, drugs and complications had a comparable pattern. Considering also hospital admission occurring only in subjects not treated with colostrum, caused by respiratory complications, the costs difference between colostrum and non- colostrum subjects is clinically very important.
Conclusions. In conclusion colostrum administration is at least 3 times more effective than vaccination to prevent flu. It is also very cost-effective.