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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 October;163(5):153-7
Clinical and epidemiological remarks on a series of hepatitis by Epstein-Barr virus
Pellicanò S. 1, Calzone R. 2, Bertuccio A. 3, Rombolà F. 2, Bertuccio S. N. 3
1 A.S.L. 5, Ospedale “S.Giovanni di Dio”, U.O. “Malattie Infettive”, Crotone;
2 Regione Calabria, A.S.L. 8, Ospedale “G. Jazzolino”, U.O. “Malattie Infettive”, Vibo Valentia;
3 A.S.L. 8, Ospedale “G. Jazzolino”
Aim. Hepatitis is a well-recognized complication of Epstein-Barr virus (EBV) infection that usually resolves spontaneously. The aim of the study was to describe the personal experience in a series of 22 cases of EBV hepatitis observed at the local health service ASL 8 of Vibo Valentia, (Calabria Region), in the period 2000-2003.
Methods. A series of 57 cases of infectious mononucleosis was examined. The diagnostic method is based on VCA-EBNA-IgM positivity.
Results. A total of 39% of patients, 14 male and 8 female were positive for hepatitis. Agreement is expressed with other series as regards the most involved age classes and absence of jaundice. Fever,sorethroat, hepatosplenomegaly were prominent findings.
Conclusion. In literature, many complications of infectious mononucleosis are described. Jaundice occasionally results from the unusual complication of autoimmune hemolytic anemia rather than hepatitis. Icteric hepatitis and fulminant failure are rare in infectious mononucleosis. The prevalence of hepatitis complication in our series is pointed out. In susceptible individuals EBV is a trigger for autoimmune hepatitis. EBV infection causing hepatitis and fulminant hepatic failure should be suspected when tests for other hepatotrophic viral infections are negative.