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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 August;163(4):121-5
Male breast cancer: report of two cases
Panier Suffat P., Bianco A., Calello G., Guffanti P., Monticone C., Ramellini G., Tozzi D., Tridico F., Truda G., Panier Suffat L.
Sezione di Chirurgia Generale e Oncologica, Dipartimento di Discipline Medico-Chirurgiche, Università degli Studi di Torino, Torino
Male breast cancer is a rare neoplasm with an incidence of about 1% of all breast cancer in both genders. Many factors are involved in the pathogenesis such as gynecomastia, hereditary and genetic factors, estrogen administration and diseases associated with hyperestrogenism.
Two cases of male breast cancer are reported and the etiologic and prognostic factors, the diagnostic work-up and surgical and complementary therapy are examined. Male breast cancer, compared with the female one, is characterized by a higher hormone receptors positivity. The neoplasm site, more frequently located in the subareolar region, may delay diagnosis and treatment. The treatment of choice is total mastectomy with axillary lymphoadenectomy according to Patey or to Halsted. Adjuvant chemotherapy and radiotherapy are often associated. The prognosis in both genders is about the same for each stage but, for the relatively low incidence of the pathology in men, diagnosis is made in a more advanced stage with a worse prognosis.