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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Fietta P. 1, Manganelli P. 1, Martella E. M. 2, Quaini F. 3
1 Unit of Rheumatology and Internal Medicine Osteo-Articular Department, General Hospital of Parma, Italy;
2 Section of Histology and Anatomopathology Department of Laboratory Pathology, University of Parma, Parma, Italy;
3 Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy
A 63-year-old woman, suffering from longstanding primary Sjögren’s syndrome (pSS), abruptly developed superficial lymphadeno-pathies. A lymph node biopsy revealed effacement of the nodal architecture by multiple noncaseating granulomas, constituted by epithelioid and multinucleated giant cells, surrounded by a large number of lymphocytes with a predominance of CD4+ T helper cells. High resolution computed tomography of the chest showed multiple bilateral small subpleural nodules and small areas of consolidation. The diagnosis of sarcoidosis complicating pSS was made. Corticosteroid therapy led to a prompt and complete regression of both lymphadenopathies and pulmonary findings. The appearance of lymphadenopathies in pSS patients requires a careful clinical examination, due to the high risk of lymphoma development; however, the case here reported underlines that sarcoidosis has always to be included in the differential diagnosis of lymph node enlargement in pSS.