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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 August;163(4):99-102
Intra-articular hyaluronic acid infiltration in the treatment of gonarthrosis
Mele G., Faraoni S. A., Missud S., Aloe S.
Divisione di Terapia Fisica e Riabilitazione, Istituto Ortopedico G. Pini, Milano
Aim. The treatment of arthrosis with intra-articular infiltrations of hyaluronic acid (HA) has received ever more attention during the last years and has proven to be particularly useful in the treatment of gonarthrosis, with an improvement in articular function and a reduction of pain.
Methods. Between June 1997 and July 1998, 63 patients with gonarthrosis were involved in a prospective study in which they underwent a cycle of weekly intra-articular infiltrations of HA for a total of 5 treatment sessions.
Results. Mean points on the WOMAC scale significantly decreased after the treatment (36.1 vs 19.7; p-value <0.0001). Considering subjective evaluation, 29% of patients reported no advantages with the treatment, in 22% of cases benefits lasted less than 2 years whilst in 49% they lasted up to the 2-year follow-up.
Conclusion. The efficacy of HA can already be observed after the first treatment sessions and lasts in time. It would be useful to evaluate its association with physiokinesitherapic rehabilitation.