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A Journal on Internal Medicine and Pharmacology

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 April;163(2):49-58

language: English

Min­er­al and bio­chem­i­cal meas­ure­ments dur­ing ­acute and rig­or­ous bed ­rest to dis­close bio­chem­i­cal chang­e dur­ing ­acute bed ­rest in ­healthy sub­jects

Zorbas Y. G., Kakurin V. J., Charapakhin K. P., Kuznetsov N. A.

Euro­pe­an Foun­da­tion of Envi­ron­men­tal Sci­enc­es, Ath­ens, ­Greece


Aim. The aim of ­this ­work was to meas­ure ­fluid absorption, plas­ma and uri­nary bio­chem­i­cal indi­ces dur­ing ­acute rig­or­ous bed ­rest (ABR). The objective of the study was also to dis­close if ABR ­or rig­or­ous bed ­rest (RBR) ­could ­affect sig­nif­i­cant­ly ­more ­fluid reten­tion and con­se­quent­ly bio­chem­i­cal var­i­ables in ­healthy sub­jects.
Meth­ods. Stud­ies ­were con­duct­ed dur­ing 3-day pre-bed ­rest (BR) and dur­ing 7-­days of ABR and RBR peri­ods. Thir­ty ­healthy ­male indi­vid­u­als, 25.2±6.4 ­years of age, ­were cho­sen as sub­jects. ­They ­were divid­ed equal­ly ­into 3 ­groups: unre­strict­ed ­active con­trol sub­jects (­UACS), ­acute bed rest­ed ­subjects (­ABRS) and rig­or­ous bed rest­ed sub­jects (­RBRS). ­ABRS con­fined abrupt­ly to RBR, and ­they did not ­have any ­prior knowl­edge of the ­exact ­date and ­time ­when ­they ­would be ­asked to be con­fined in bed. ­RBRS ­were sub­ject­ed to RBR on a pre­de­ter­mined ­date and ­time ­known to ­them ­right ­from the ­start of the ­study. ­UACS ­were not sub­ject­ed to any ­form of BR.
­Results. Uri­nary and plas­ma sodi­um (Na+), potas­sium (K+), cal­cium (Ca2+), mag­ne­sium (Mg2+) lev­els, ­whole ­blood hae­mog­lo­bin (Hb), hem­a­toc­rit (Hot), plas­ma ­renin activ­ity (PA), plas­ma aldos­te­rone (PA), uri­nary excre­tion, uri­nary crea­ti­nine and ­urea lev­els ­increased sig­nif­i­cant­ly (p<0.05), ­while ­fluid absorp­tion, uri­nary osmo­lar­ity and ­fluid con­sump­tion ­decreased sig­nif­i­cant­ly (p<0.05) in ­ABRS and ­RBRS ­when com­pared ­with ­their pre-bed ­rest val­ues and the val­ues in ­UACS. How­ev­er, ­fluid absorption, uri­nary and plas­ma elec­tro­lytes and bio­chem­i­cal var­i­ables ­changed sig­nif­i­cant­ly (p<0.05) ­more and sig­nif­i­cant­ly (p<0.05) fast­er in ­ABRS ­than ­RBRS. Con­verse­ly, uri­nary and plas­ma Na+, K+, Ca2+, and Mg2+ lev­els, ­whole ­blood Hb, Hct, PRA, PA, uri­nary osmo­lar­ity, crea­ti­nine, ­urea lev­els, ­fluid absorp­tion, ­fluid con­sump­tion and ­fluid elim­i­na­tion ­leves did not ­change in ­UACS com­pared ­with ­their pre-bed ­rest val­ues.
Con­clu­sion. The sig­nif­i­cant­ly great­er bio­chem­i­cal chang­es in ­ABRS ­than ­RBRS may dem­on­strate ­that plas­ma and uri­nary bio­chem­is­try is affect­ed sig­nif­i­cant­ly ­more in ­ABRS ­than ­RBRS. It was con­clud­ed, the ­more abrupt­ly mus­cu­lar activ­ity is restrict­ed the great­er elec­tro­lyte and bio­chem­i­cal chang­es in ­healthy sub­jects and prob­ably in indi­vid­u­als ­whose mus­cu­lar activ­ity is abrupt­ly ter­mi­nat­ed.

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