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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 April;163(2):49-58
Mineral and biochemical measurements during acute and rigorous bed rest to disclose biochemical change during acute bed rest in healthy subjects
Zorbas Y. G., Kakurin V. J., Charapakhin K. P., Kuznetsov N. A.
European Foundation of Environmental Sciences, Athens, Greece
Aim. The aim of this work was to measure fluid absorption, plasma and urinary biochemical indices during acute rigorous bed rest (ABR). The objective of the study was also to disclose if ABR or rigorous bed rest (RBR) could affect significantly more fluid retention and consequently biochemical variables in healthy subjects.
Methods. Studies were conducted during 3-day pre-bed rest (BR) and during 7-days of ABR and RBR periods. Thirty healthy male individuals, 25.2±6.4 years of age, were chosen as subjects. They were divided equally into 3 groups: unrestricted active control subjects (UACS), acute bed rested subjects (ABRS) and rigorous bed rested subjects (RBRS). ABRS confined abruptly to RBR, and they did not have any prior knowledge of the exact date and time when they would be asked to be confined in bed. RBRS were subjected to RBR on a predetermined date and time known to them right from the start of the study. UACS were not subjected to any form of BR.
Results. Urinary and plasma sodium (Na+), potassium (K+), calcium (Ca2+), magnesium (Mg2+) levels, whole blood haemoglobin (Hb), hematocrit (Hot), plasma renin activity (PA), plasma aldosterone (PA), urinary excretion, urinary creatinine and urea levels increased significantly (p<0.05), while fluid absorption, urinary osmolarity and fluid consumption decreased significantly (p<0.05) in ABRS and RBRS when compared with their pre-bed rest values and the values in UACS. However, fluid absorption, urinary and plasma electrolytes and biochemical variables changed significantly (p<0.05) more and significantly (p<0.05) faster in ABRS than RBRS. Conversely, urinary and plasma Na+, K+, Ca2+, and Mg2+ levels, whole blood Hb, Hct, PRA, PA, urinary osmolarity, creatinine, urea levels, fluid absorption, fluid consumption and fluid elimination leves did not change in UACS compared with their pre-bed rest values.
Conclusion. The significantly greater biochemical changes in ABRS than RBRS may demonstrate that plasma and urinary biochemistry is affected significantly more in ABRS than RBRS. It was concluded, the more abruptly muscular activity is restricted the greater electrolyte and biochemical changes in healthy subjects and probably in individuals whose muscular activity is abruptly terminated.