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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 April;163(2):43-8
Evaluation of ovulation regularity in relation to insulin hematic levels, androgens and obesity in polycistic ovary syndrome
Gambardella V., D'Ettore A., Battista L., Vitelli A., Giannotti F., D'Antò V., Caccavale C., Sole E., Tolino A.
Dipartimento di Scienze Ostetrico-Ginecologiche Urologiche e Medicina della Riproduzione, Università degli Studi di Napoli, «Federico II», Napoli
Aim. The ovary polycystic syndrome (PCOS) is probably the most frequent endocrinopathy in reproductive age women. It is characterized by hyperandrogenism and chronic anovulation, in absence of other pathologies which can be the cause of these manifestations. The aim of this study was to evaluate the ovulatory regularity considering the hematic levels of insulin, androgens and obesity in PCOS.
Methods. A total of 238 women with PCOS subdivided into 2 groups have been studied: 214 patients with anovulatory cycles and 24 with regular and ovulatory cycles. The high hematic levels of insulin, insulin-resistance, body mass index (BMI), androstenedione, testosterone, free testosterone, sulfate-Dehydroepiandrosterone, and irsutism have been evaluated.
Results. The results obtained showed that women with PCOS with ovulatory and regular cycles have more normal weight and insulin hematic levels and are less over-weight-obese and irsute than anovulatory women. The lowest values of insulin, androgens, testosterone and free testosterone are observed in ovulatory women.
Conclusion. Obesity, which induces insulin-resistance and high hematic levels of insulin, contributes to the development of PCOS in some women, adding a type of insulin-resistance particular obesity to the pre-existent insulin-resistance associated to PCOS. In PCOS patients obesity makes worse the syndrome. In particular, insulin-resistance proves to be associated to BMI, while weight reduction in obese patients with PCOS reduces LH-hyperincretion and restores a normal insulin-sensibility.