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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 February;163(1):5-9
Treatment with genistein and cimicifuga racemosa. Personal experience
Mainini G., Torella M., Ragucci A.
II Centro Menopausa, Dipartimento di Scienze Ginecologiche, Ostetriche e della Riproduzione, Seconda Università degli Studi di Napoli, Napoli
Aim. Phytoestrogens are natural, non-steroid substances contained in plants. They are so called because their actions and structures are similar to those of estrogen hormones although with a power 1 000-10 000 times less strong. Certain soya phytoestrogens (genistein and daidzein) possess a chemical conformation very similar to that of estradiol, so much so that it is though that they act through an effect of selective modulation on estrogenic receptors. In the present paper we report our personal experience in the use of genistein in patients in the perimenopause who were not receiving substitutive hormone therapy and the results are reported in terms of prevention and reduction of menopausal symptoms (Kupperman’s index).
Methods. Twenty-eight perimenopause patients who were not receiving HRT were treated with 85% genistein associated with 50% fructo-oligosaccharides, magnesium pidolate, Lactobacillus acidophilus, 50% vitamin E acetate, cimicifuga racemosa root powder, Streptococcus termophilus, cholecalciferol and bibasic calcium phosphate. There was also a control group of 11 patients showing the same clinical characteristics, treated with calcium and vitamin D3. Average age was 50.05. The extent of menopausal symptoms was evaluated by means of Kupperman’s Index.
Results. Three months after the start of treatment both the Kupperman Index and the heat flushes were reduced in a statistically significant manner (p <0.01) while these parameters werenot significantly modified in the control group.
Conclusion. Our study highlights a generally good tolerance of genistein and of the other associated active principles both 1 month and 3 months from the start of treatment. The effect on vasomotor symptomatology was fair. It will be interesting to observe if there is any effect on the lipid metabolism and on the coagulative picture after 6 and 12 months of treatment.