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A Journal on Internal Medicine and Pharmacology

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 February;163(1):5-9

language: Italian

Treat­ment ­with genis­te­in and cimic­i­fu­ga rac­e­mo­sa. Per­son­al expe­ri­ence

Mainini G., Torella M., Ragucci A.

II Centro Menopausa, Dipartimento di Scienze Ginecologiche, Ostetriche e della Riproduzione, Seconda Università degli Studi di Napoli, Napoli


Aim. Phy­toes­tro­gens are nat­u­ral, non-ster­oid sub­stanc­es con­tained in ­plants. ­They are so ­called ­because ­their ­actions and struc­tures are sim­i­lar to ­those of estro­gen hor­mones ­although ­with a pow­er 1 000-10 000 ­times ­less ­strong. Cer­tain ­soya phy­toes­tro­gens (genis­te­in and daid­ze­in) pos­sess a chem­i­cal con­for­ma­tion ­very sim­i­lar to ­that of estrad­i­ol, so ­much so ­that it is ­though ­that ­they act ­through an ­effect of selec­tive mod­ula­tion on estro­gen­ic recep­tors. In the ­present ­paper we ­report our per­son­al expe­ri­ence in the use of genis­te­in in ­patients in the per­i­men­o­pause who ­were not receiv­ing sub­sti­tu­tive hor­mone ther­a­py and the ­results are report­ed in ­terms of pre­ven­tion and reduc­tion of men­o­pau­sal symp­toms (­Kupperman’s ­index).
Meth­ods. Twen­ty-­eight per­i­men­o­pause ­patients who ­were not receiv­ing HRT ­were treat­ed ­with 85% genis­te­in asso­ciat­ed ­with 50% fruc­to-olig­o­sac­cha­rides, mag­ne­sium pid­o­late, Lac­tob­a­cil­lus aci­doph­i­lus, 50% vita­min E ace­tate, cimic­i­fu­ga rac­e­mo­sa ­root pow­der, Strep­to­coc­cus ter­moph­i­lus, chol­e­cal­cif­e­rol and bibas­ic cal­cium phos­phate. ­There was ­also a con­trol ­group of 11 ­patients show­ing the ­same clin­i­cal char­ac­ter­is­tics, treat­ed ­with cal­cium and vita­min D3. Aver­age age was 50.05. The ­extent of men­o­pau­sal symp­toms was eval­u­at­ed by ­means of ­Kupperman’s ­Index.
­Results. ­Three ­months ­after the ­start of treat­ment ­both the Kup­per­man ­Index and the ­heat flush­es ­were ­reduced in a sta­tis­ti­cal­ly sig­nif­i­cant man­ner (p <0.01) ­while ­these param­e­ters werenot sig­nif­i­cant­ly mod­i­fied in the con­trol ­group.
Con­clu­sion. Our ­study high­lights a gen­er­al­ly ­good tol­er­ance of genis­te­in and of the oth­er asso­ciat­ed ­active prin­ci­ples ­both 1 ­month and 3 ­months ­from the ­start of treat­ment. The ­effect on vas­o­mo­tor symp­tom­a­tol­o­gy was ­fair. It ­will be inter­est­ing to ­observe if ­there is any ­effect on the lip­id metab­olism and on the coag­u­la­tive pic­ture ­after 6 and 12 ­months of treat­ment.

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