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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2003 December;162(6):147-53

language: English

Recur­rent idiopath­ic ­deep ­vein throm­bo­sis and hyper­hom­o­cys­tei­ne­mia. An evi­dence ­based ­case ­report

Cei M. 1, Mumoli N. 2

1 Depart­ment of Inter­nal Med­i­cine 2, Civil­ian Hos­pi­tal, USL 6, Livor­no, Ita­ly;
2 Depart­ment of Emer­gen­cy Med­i­cine, Civil­ian Hos­pi­tal, USL 6, Livor­no, Ita­ly


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Acquired or hered­i­tary derange­ments in meth­ion­in meta­bol­ic path­ways may ­result in ­mild hyper­hom­o­cys­tei­ne­mia, lead­ing in ­turn to hyper­coa­gu­labil­ity and to ­venous throm­boem­bo­lism. How­ev­er, ­some ­basic, epi­dem­i­olog­i­cal and ther­a­peu­tic ­aspects of ­this con­di­tion ­remain to be com­plete­ly ascer­tained. As a ­result, deci­sion mak­ing in clin­i­cal prac­tice may be not ­always sim­ple and sup­port­ed by ­clear experi­men­tal evi­dence. The ­authors ­review the ­role of hyper­hom­o­cys­tei­ne­mia ­from muta­tion of the meth­yl­enet­e­tra­hy­drof­o­late reduc­tase ­gene as a ­cause of recur­rent ­deep ­vein throm­bo­sis.

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