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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Cei M. 1, Mumoli N. 2
1 Department of Internal Medicine 2, Civilian Hospital, USL 6, Livorno, Italy;
2 Department of Emergency Medicine, Civilian Hospital, USL 6, Livorno, Italy
Acquired or hereditary derangements in methionin metabolic pathways may result in mild hyperhomocysteinemia, leading in turn to hypercoagulability and to venous thromboembolism. However, some basic, epidemiological and therapeutic aspects of this condition remain to be completely ascertained. As a result, decision making in clinical practice may be not always simple and supported by clear experimental evidence. The authors review the role of hyperhomocysteinemia from mutation of the methylenetetrahydrofolate reductase gene as a cause of recurrent deep vein thrombosis.