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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2003 October;162(5):117-20
Local administration of soy isoflavones in postmenopausal vulvovaginal disease
Morgante G., La Marca A., Lanzetta D., Musacchio M. C., De Leo V.
Dipartimento di Pediatria, Ostetricia e Medicina della Riproduzione, Clinica Ostetrica e Ginecologica, Università degli Studi di Siena, Siena
Aim. Hormonal replacement therapy (HRT) is safe and effective in the relief of postmenopausal symptoms. For the genital tract (vaginal dryness and thinning of genital tissue) a local estrogen therapy can be used. If the patient prefers to avoid hormones, there are some preparations with soy isoflavones extracts that locally applied induce relief of urogenital symptomatology caused by estrogen loss.
Methods. Thirty healthy menopausal women (>1 year) with urogenital diseases were examined, randomly divided into 2 groups and treated for 3 months: group A, 18 women treated with soy isoflavones cream (1 vaginal application daily); group B, 12 women treated with a moisture gel. Local symptomatology was evaluated: dryness, dyspareunia e itch-burning.
Results. Both groups showed improvement in symptomatology. In group A there was a significant reduction (p<0.005) compared to group B at the 1st and 3rd month of therapy for dyspareunia and itch-burning. Dryness showed the same reduction in both groups.
Conclusion. The possibility to use a preparation like that used in the present study with an adequate dose of soy isoflavones makes it possible not only to treat, with a continued use, vulvo-vaginal symptomatology but to prevent its appearance.